{"symbol":"TYMS","synonyms":["HST422","TMS"],"name":"thymidylate synthetase","description":"Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]","ncbiEntrezGeneId":7298,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7298","proteins":[{"symbol":"TYSY_HUMAN","href":"/api/1.0/protein/TYSY_HUMAN"}],"hgncRootFamilies":[]}