{"symbol":"UBA1","synonyms":["AMCX1","UBA1A","A1S9T","UBE1X","CFAP124","UBE1","A1ST","SMAX2","A1S9","GXP1","POC20"],"name":"ubiquitin-like modifier activating enzyme 1","description":"The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":7317,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7317","proteins":[{"symbol":"UBA1_HUMAN","href":"/api/1.0/protein/UBA1_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-like activating enzymes (UBA)","href":"/api/1.0/gene_family/Ubiquitin-like+activating+enzymes+%28UBA%29"}]}