{"symbol":"UBA2","synonyms":["ARX","HRIHFB2115"],"name":"ubiquitin-like modifier activating enzyme 2","description":"Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]","ncbiEntrezGeneId":10054,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10054","proteins":[{"symbol":"SAE2_HUMAN","href":"/api/1.0/protein/SAE2_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-like activating enzymes (UBA)","href":"/api/1.0/gene_family/Ubiquitin-like+activating+enzymes+%28UBA%29"}]}