{"symbol":"UBA3","synonyms":["NAE2","UBE1C","HUBA3"],"name":"ubiquitin-like modifier activating enzyme 3","description":"The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":9039,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9039","proteins":[{"symbol":"UBA3_HUMAN","href":"/api/1.0/protein/UBA3_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-like activating enzymes (UBA)","href":"/api/1.0/gene_family/Ubiquitin-like+activating+enzymes+%28UBA%29"}]}