{"symbol":"UBA7","synonyms":["UBE1L","UBE2","UBA1B","D8"],"name":"ubiquitin-like modifier activating enzyme 7","description":"The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":7318,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7318","proteins":[{"symbol":"UBA7_HUMAN","href":"/api/1.0/protein/UBA7_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-like activating enzymes (UBA)","href":"/api/1.0/gene_family/Ubiquitin-like+activating+enzymes+%28UBA%29"}]}