{"symbol":"UBE2A","synonyms":["RAD6A","HHR6A","MRXS30","UBC2","MRXSN"],"name":"ubiquitin-conjugating enzyme E2A","description":"The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]","ncbiEntrezGeneId":7319,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7319","proteins":[{"symbol":"UBE2A_HUMAN","href":"/api/1.0/protein/UBE2A_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-conjugating enzymes E2 (UBE2)","href":"/api/1.0/gene_family/Ubiquitin-conjugating+enzymes+E2+%28UBE2%29"}]}