{"symbol":"UBE2B","synonyms":["HR6B","E2-17KDA","HHR6B","RAD6B"],"name":"ubiquitin-conjugating enzyme E2B","description":"The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":7320,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7320","proteins":[{"symbol":"UBE2B_HUMAN","href":"/api/1.0/protein/UBE2B_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-conjugating enzymes E2 (UBE2)","href":"/api/1.0/gene_family/Ubiquitin-conjugating+enzymes+E2+%28UBE2%29"}]}