{"symbol":"UBE2D2","synonyms":["E2(17)KB2","UBCH4","PUBC1","UBCH5B","UBC4"],"name":"ubiquitin-conjugating enzyme E2D 2","description":"Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]","ncbiEntrezGeneId":7322,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7322","proteins":[{"symbol":"UB2D2_HUMAN","href":"/api/1.0/protein/UB2D2_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-conjugating enzymes E2 (UBE2)","href":"/api/1.0/gene_family/Ubiquitin-conjugating+enzymes+E2+%28UBE2%29"}]}