{"symbol":"UBE2D3","synonyms":["UBCH5C","E2(17)KB3"],"name":"ubiquitin-conjugating enzyme E2D 3","description":"The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017]","ncbiEntrezGeneId":7323,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7323","proteins":[{"symbol":"UB2D3_HUMAN","href":"/api/1.0/protein/UB2D3_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-conjugating enzymes E2 (UBE2)","href":"/api/1.0/gene_family/Ubiquitin-conjugating+enzymes+E2+%28UBE2%29"}]}