{"symbol":"UBE2E2","synonyms":["UBCH8"],"name":"ubiquitin-conjugating enzyme E2E 2","description":"Enables ISG15 transferase activity and ubiquitin conjugating enzyme activity. Involved in protein modification by small protein conjugation. Acts upstream of or within DNA damage response and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. Implicated in type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":7325,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7325","proteins":[{"symbol":"UB2E2_HUMAN","href":"/api/1.0/protein/UB2E2_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-conjugating enzymes E2 (UBE2)","href":"/api/1.0/gene_family/Ubiquitin-conjugating+enzymes+E2+%28UBE2%29"}]}