{"symbol":"UBE2K","synonyms":["UBC1","E2-25K","HIP2","HYPG","LIG"],"name":"ubiquitin-conjugating enzyme E2K","description":"The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington\u0027s disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3093,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3093","proteins":[{"symbol":"UBE2K_HUMAN","href":"/api/1.0/protein/UBE2K_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-conjugating enzymes E2 (UBE2)","href":"/api/1.0/gene_family/Ubiquitin-conjugating+enzymes+E2+%28UBE2%29"}]}