{"symbol":"UBE2L3","synonyms":["UBCH7","E2-F1","UBCM4","L-UBC"],"name":"ubiquitin-conjugating enzyme E2L 3","description":"The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]","ncbiEntrezGeneId":7332,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7332","proteins":[{"symbol":"UB2L3_HUMAN","href":"/api/1.0/protein/UB2L3_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-conjugating enzymes E2 (UBE2)","href":"/api/1.0/gene_family/Ubiquitin-conjugating+enzymes+E2+%28UBE2%29"}]}