{"symbol":"UBE2M","synonyms":["UBC12","UBC-RS2","HUBC12"],"name":"ubiquitin-conjugating enzyme E2M","description":"The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":9040,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9040","proteins":[{"symbol":"UBC12_HUMAN","href":"/api/1.0/protein/UBC12_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-conjugating enzymes E2 (UBE2)","href":"/api/1.0/gene_family/Ubiquitin-conjugating+enzymes+E2+%28UBE2%29"}]}