{"symbol":"UBE3B","synonyms":["KOS","BPIDS"],"name":"ubiquitin protein ligase E3B","description":"The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]","ncbiEntrezGeneId":89910,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/89910","proteins":[{"symbol":"UBE3B_HUMAN","href":"/api/1.0/protein/UBE3B_HUMAN"}],"hgncRootFamilies":[]}