{"symbol":"UBE4A","synonyms":["E4","UBOX2","UFD2"],"name":"ubiquitination factor E4A","description":"This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn\u0027s disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]","ncbiEntrezGeneId":9354,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9354","proteins":[{"symbol":"UBE4A_HUMAN","href":"/api/1.0/protein/UBE4A_HUMAN"}],"hgncRootFamilies":[{"name":"U-box domain containing (UBOX)","href":"/api/1.0/gene_family/U-box+domain+containing+%28UBOX%29"}]}