{"symbol":"UBN1","synonyms":["VT","VT4"],"name":"ubinuclein 1","description":"Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]","ncbiEntrezGeneId":29855,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/29855","proteins":[{"symbol":"UBN1_HUMAN","href":"/api/1.0/protein/UBN1_HUMAN"}],"hgncRootFamilies":[{"name":"Protein phosphatase 1 regulatory subunits (PPP1R)","href":"/api/1.0/gene_family/Protein+phosphatase+1+regulatory+subunits+%28PPP1R%29"}]}