{"symbol":"UBR5","synonyms":["HYD","DD5","EDD1","EDD"],"name":"ubiquitin protein ligase E3 component n-recognin 5","description":"This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":51366,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51366","proteins":[{"symbol":"UBR5_HUMAN","href":"/api/1.0/protein/UBR5_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin protein ligase E3 component n-recognins (UBR)","href":"/api/1.0/gene_family/Ubiquitin+protein+ligase+E3+component+n-recognins+%28UBR%29"}]}