{"symbol":"UHRF2","synonyms":["RNF107","TDRD23","URF2"],"name":"ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase","description":"This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]","ncbiEntrezGeneId":115426,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/115426","proteins":[{"symbol":"UHRF2_HUMAN","href":"/api/1.0/protein/UHRF2_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}