{"symbol":"ULBP1","synonyms":["NKG2DL1","RAET1I","N2DL-1"],"name":"UL16 binding protein 1","description":"The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]","ncbiEntrezGeneId":80329,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/80329","proteins":[{"symbol":"N2DL1_HUMAN","href":"/api/1.0/protein/N2DL1_HUMAN"}],"hgncRootFamilies":[]}