{"symbol":"UNC45B","synonyms":["UNC-45B","CMYA4","SMUNC45","UNC45","CTRCT43"],"name":"unc-45 homolog B (C. elegans)","description":"This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]","ncbiEntrezGeneId":146862,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/146862","proteins":[{"symbol":"UN45B_HUMAN","href":"/api/1.0/protein/UN45B_HUMAN"}],"hgncRootFamilies":[]}