{"symbol":"UPB1","synonyms":["BUP1"],"name":"ureidopropionase, beta","description":"This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":51733,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51733","proteins":[{"symbol":"BUP1_HUMAN","href":"/api/1.0/protein/BUP1_HUMAN"}],"hgncRootFamilies":[]}