{"symbol":"UPF1","synonyms":["SMG-2","PNORF1","NORF1","HUPF1","RENT1"],"name":"UPF1 regulator of nonsense transcripts homolog (yeast)","description":"This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]","ncbiEntrezGeneId":5976,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5976","proteins":[{"symbol":"RENT1_HUMAN","href":"/api/1.0/protein/RENT1_HUMAN"}],"hgncRootFamilies":[]}