{"symbol":"USP14","synonyms":["TGT"],"name":"ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)","description":"This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":9097,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9097","proteins":[{"symbol":"UBP14_HUMAN","href":"/api/1.0/protein/UBP14_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-specific peptidases (USP)","href":"/api/1.0/gene_family/Ubiquitin-specific+peptidases+%28USP%29"}]}