{"symbol":"USP5","synonyms":["ISOT"],"name":"ubiquitin specific peptidase 5 (isopeptidase T)","description":"Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]","ncbiEntrezGeneId":8078,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8078","proteins":[{"symbol":"UBP5_HUMAN","href":"/api/1.0/protein/UBP5_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-specific peptidases (USP)","href":"/api/1.0/gene_family/Ubiquitin-specific+peptidases+%28USP%29"}]}