{"symbol":"UVRAG","synonyms":["DHTX","VPS38"],"name":"UV radiation resistance associated","description":"This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":7405,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7405","proteins":[{"symbol":"UVRAG_HUMAN","href":"/api/1.0/protein/UVRAG_HUMAN"}],"hgncRootFamilies":[{"name":"C2 domain containing","href":"/api/1.0/gene_family/C2+domain+containing"}]}