{"symbol":"VAMP2","synonyms":["SYB2","VAMP-2"],"name":"vesicle-associated membrane protein 2 (synaptobrevin 2)","description":"The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6844,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6844","proteins":[{"symbol":"VAMP2_HUMAN","href":"/api/1.0/protein/VAMP2_HUMAN"}],"hgncRootFamilies":[{"name":"Vesicle-associated membrane proteins (VAMP)","href":"/api/1.0/gene_family/Vesicle-associated+membrane+proteins+%28VAMP%29"}]}