{"symbol":"VCX","synonyms":["VCX1","VCX10R","VCX-B1","VCXB1","VCX-10R"],"name":"variable charge, X-linked","description":"This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":26609,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/26609","proteins":[{"symbol":"VCX1_HUMAN","href":"/api/1.0/protein/VCX1_HUMAN"}],"hgncRootFamilies":[{"name":"Variable charge X/Y family (VCX, VCY)","href":"/api/1.0/gene_family/Variable+charge+X%24slash%24Y+family+%28VCX%2C+VCY%29"}]}