{"symbol":"VKORC1","synonyms":["EDTP308","VKOR","MST134","IMAGE3455200","VKCFD2","MST576"],"name":"vitamin K epoxide reductase complex, subunit 1","description":"This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]","ncbiEntrezGeneId":79001,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/79001","proteins":[{"symbol":"VKOR1_HUMAN","href":"/api/1.0/protein/VKOR1_HUMAN"}],"hgncRootFamilies":[]}