{"symbol":"VPRBP","synonyms":["DCAF1"],"name":"Vpr (HIV-1) binding protein","description":"Enables histone H2AT120 kinase activity; nuclear estrogen receptor binding activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including cell competition in a multicellular organism; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of primary metabolic process. Located in COP9 signalosome; fibrillar center; and nucleoplasm. Part of Cul4-RING E3 ubiquitin ligase complex. Is active in centrosome. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":9730,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9730","proteins":[{"symbol":"VPRBP_HUMAN","href":"/api/1.0/protein/VPRBP_HUMAN"}],"hgncRootFamilies":[{"name":"DDB1 and CUL4 associated factors (DCAF)","href":"/api/1.0/gene_family/DDB1+and+CUL4+associated+factors+%28DCAF%29"}]}