{"symbol":"VPREB1","synonyms":["CD179A","VPREB","IGI"],"name":"pre-B lymphocyte 1","description":"The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]","ncbiEntrezGeneId":7441,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7441","proteins":[{"symbol":"VPREB_HUMAN","href":"/api/1.0/protein/VPREB_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}