{"symbol":"VPS35","synonyms":["MEM3","PARK17"],"name":"vacuolar protein sorting 35 homolog (S. cerevisiae)","description":"This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":55737,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55737","proteins":[{"symbol":"VPS35_HUMAN","href":"/api/1.0/protein/VPS35_HUMAN"}],"hgncRootFamilies":[{"name":"Parkinson disease associated genes (PARK)","href":"/api/1.0/gene_family/Parkinson+disease+associated+genes+%28PARK%29"}]}