{"symbol":"VPS72","synonyms":["YL1","TCFL1","CFL1","SWC2","YL-1"],"name":"vacuolar protein sorting 72 homolog (S. cerevisiae)","description":"The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]","ncbiEntrezGeneId":6944,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6944","proteins":[{"symbol":"VPS72_HUMAN","href":"/api/1.0/protein/VPS72_HUMAN"}],"hgncRootFamilies":[]}