{"symbol":"WASF1","synonyms":["WAVE1","WAVE","SCAR1"],"name":"WAS protein family, member 1","description":"The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8936,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8936","proteins":[{"symbol":"WASF1_HUMAN","href":"/api/1.0/protein/WASF1_HUMAN"}],"hgncRootFamilies":[{"name":"A-kinase anchor proteins (AKAP)","href":"/api/1.0/gene_family/A-kinase+anchor+proteins+%28AKAP%29"},{"name":"Wiskott-Aldrich Syndrome protein family","href":"/api/1.0/gene_family/Wiskott-Aldrich+Syndrome+protein+family"}]}