{"symbol":"WDFY3","synonyms":["ZFYVE25","MCPH18","ALFY","BCHS"],"name":"WD repeat and FYVE domain containing 3","description":"This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]","ncbiEntrezGeneId":23001,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23001","proteins":[{"symbol":"WDFY3_HUMAN","href":"/api/1.0/protein/WDFY3_HUMAN"}],"hgncRootFamilies":[{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}