{"symbol":"WDR11","synonyms":["DR11","SRI1","HH14","WDR15"],"name":"WD repeat domain 11","description":"This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":55717,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55717","proteins":[{"symbol":"WDR11_HUMAN","href":"/api/1.0/protein/WDR11_HUMAN"}],"hgncRootFamilies":[{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"}]}