{"symbol":"WDR4","synonyms":["TRM82","TRMT82"],"name":"WD repeat domain 4","description":"This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]","ncbiEntrezGeneId":10785,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10785","proteins":[{"symbol":"WDR4_HUMAN","href":"/api/1.0/protein/WDR4_HUMAN"}],"hgncRootFamilies":[{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"}]}