{"symbol":"WFDC8","synonyms":["WAP8","DJ461P17.1","HEL-S-292","C20ORF170"],"name":"WAP four-disulfide core domain 8","description":"This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains a Kunitz-inhibitor domain, in addition to three WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode the same protein. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":90199,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/90199","proteins":[{"symbol":"WFDC8_HUMAN","href":"/api/1.0/protein/WFDC8_HUMAN"}],"hgncRootFamilies":[{"name":"WAP four-disulfide core domain containing (WFDC)","href":"/api/1.0/gene_family/WAP+four-disulfide+core+domain+containing+%28WFDC%29"}]}