{"symbol":"WNK4","synonyms":["PRKWNK4","PHA2B"],"name":"WNK lysine deficient protein kinase 4","description":"This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]","ncbiEntrezGeneId":65266,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/65266","proteins":[{"symbol":"WNK4_HUMAN","href":"/api/1.0/protein/WNK4_HUMAN"}],"hgncRootFamilies":[]}