{"symbol":"WRN","synonyms":["RECQ3"],"name":"Werner syndrome, RecQ helicase-like","description":"This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3\u0027 to 5\u0027 exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]","ncbiEntrezGeneId":7486,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7486","proteins":[{"symbol":"WRN_HUMAN","href":"/api/1.0/protein/WRN_HUMAN"}],"hgncRootFamilies":[{"name":"Exonucleases","href":"/api/1.0/gene_family/Exonucleases"}]}