{"symbol":"XIAP","synonyms":["MIHA","XLP2","HIAP3","IAP-3","API3","HIAP-3","BIRC4","ILP1"],"name":"X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase","description":"This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]","ncbiEntrezGeneId":331,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/331","proteins":[{"symbol":"XIAP_HUMAN","href":"/api/1.0/protein/XIAP_HUMAN"}],"hgncRootFamilies":[{"name":"Baculoviral IAP repeat containing (BIRC)","href":"/api/1.0/gene_family/Baculoviral+IAP+repeat+containing+%28BIRC%29"}]}