{"symbol":"XRCC1","synonyms":["RCC","SCAR26"],"name":"X-ray repair complementing defective repair in Chinese hamster cells 1","description":"The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":7515,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7515","proteins":[{"symbol":"XRCC1_HUMAN","href":"/api/1.0/protein/XRCC1_HUMAN"}],"hgncRootFamilies":[]}