{"symbol":"XRCC3","synonyms":["CMM6"],"name":"X-ray repair complementing defective repair in Chinese hamster cells 3","description":"This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":7517,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7517","proteins":[{"symbol":"XRCC3_HUMAN","href":"/api/1.0/protein/XRCC3_HUMAN"}],"hgncRootFamilies":[]}