{"symbol":"XRCC5","synonyms":["KUB2","NFIV","KU86","KARP1","KARP-1","KU80"],"name":"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)","description":"The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events.  This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":7520,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7520","proteins":[{"symbol":"XRCC5_HUMAN","href":"/api/1.0/protein/XRCC5_HUMAN"}],"hgncRootFamilies":[]}