{"symbol":"YARS","synonyms":["YTS","CMTDIC","YRS","TYRRS"],"name":"tyrosyl-tRNA synthetase","description":"Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8565,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8565","proteins":[{"symbol":"SYYC_HUMAN","href":"/api/1.0/protein/SYYC_HUMAN"}],"hgncRootFamilies":[{"name":"Aminoacyl tRNA synthetases","href":"/api/1.0/gene_family/Aminoacyl+tRNA+synthetases"}]}