{"symbol":"YWHAZ","synonyms":["YWHAD","HEL4","HEL-S-93","HEL-S-3","14-3-3-ZETA"],"name":"tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta","description":"This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5\u0027 UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]","ncbiEntrezGeneId":7534,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7534","proteins":[{"symbol":"1433Z_HUMAN","href":"/api/1.0/protein/1433Z_HUMAN"}],"hgncRootFamilies":[]}