{"symbol":"ZAK","synonyms":["AZK","MAP3K20","MLTKalpha","MLK7","SFMMP","MLTK","MLTKbeta","pk","MLKLAK","CNM6"],"name":"sterile alpha motif and leucine zipper containing kinase AZK","description":"This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":51776,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51776","proteins":[],"hgncRootFamilies":[]}