{"symbol":"ZBTB16","synonyms":["ZNF145","PLZF"],"name":"zinc finger and BTB domain containing 16","description":"This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":7704,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7704","proteins":[{"symbol":"ZBT16_HUMAN","href":"/api/1.0/protein/ZBT16_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"},{"name":"BTB (POZ) domain containing (BTBD)","href":"/api/1.0/gene_family/BTB+%28POZ%29+domain+containing+%28BTBD%29"}]}