{"symbol":"ZNF189","synonyms":[],"name":"zinc finger protein 189","description":"Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]","ncbiEntrezGeneId":7743,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7743","proteins":[{"symbol":"ZN189_HUMAN","href":"/api/1.0/protein/ZN189_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}