{"symbol":"ZNF280B","synonyms":["D87009.C22.3","SUHW2","ZNF632","ZNF279","5\u0027OY11.1"],"name":"zinc finger protein 280B","description":"The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]","ncbiEntrezGeneId":140883,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/140883","proteins":[{"symbol":"Z280B_HUMAN","href":"/api/1.0/protein/Z280B_HUMAN"}],"hgncRootFamilies":[]}