| Description | Fitness scores for cell lines following single gene knockdowns |
| Measurement | relative cell proliferation |
| Association | gene-cell line associations by sensitivity of cell line to gene knockdown |
| Category | disease or phenotype associations |
| Resource | Achilles |
| Citation(s) |
|
| Last Updated | 2015 Apr 06 |
| Stats |
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Attribute Similarity
Gene Attribute
Gene Similarity
216 sets of gene knockdowns changing fitness of each cell line relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
| Gene Set | Description |
|---|---|
| 22RV1 | Human prostate carcinoma cell line; derived from a human prostate carcinoma xenograft (CWR22R) that was serially propagated in nude mice after castration-induced regression and relapse of the parental, androgen-dependent CWR22 xenograft. |
| 697 | Human B cell precursor leukemia; established from the bone marrow of a 12-year-old boy with acute lymphoblastic leukemia (cALL) at relapse in 1979. |
| 786O | Human renal cell adenocarcinoma cell line, established from a 58 years old caucasian male. |
| A1207 | |
| A172 | A immortal human brain-derived cell line cell that has the characteristics: Human cell line derived from glioblastoma. TKG0183(Deposited from Tohoku Univ.). |
| A204 | |
| A2058 | Human skin melanoma cell line, established from a 43 years adult caucasian male. |
| A549 | Human lung carcinoma established from an explanted lung tumor which was removed from a 58-year-old Caucasian man in 1972; cells were described to induce tumors in athymic mice and to synthesize lecithin. |
| A673 | |
| ACHN | |
| AGS | |
| AM38 | |
| AML193 | |
| ASPC1 | |
| BT20 | Human, Caucasian, breast, carcinoma cell line. Morphology: epithelial-like; species: human, Caucasian female 74 years old; tissue: breast; tumor: carcinoma. |
| BT474 | |
| BXPC3 | Human pancreatic adenocarcinoma cell line, established from a 61 year old human female. |
| C2BBE1 | The C2BBe1 (brush border expressing) cell line was cloned in 1988 from the Caco-2 cell line by limiting dilution. |
| C32 | |
| CADOES1 | |
| CAL120 | disease: adenocarcinoma, breast |
| CAL51 | |
| CALU1 | |
| CAOV3 | |
| CAOV4 | disease: adenocarcinoma (ovary primary) |
| CAS1 | |
| CFPAC1 | This line was derived from a pancreatic duct adenocarcinoma (liver metastasis) from a patient with cystic fibrosis. |
| CH157MN | cell line derived from central nervous system |
| COLO205 | |
| COLO704 | |
| COLO741 | disease: carcinoma, colon |
| COLO783 | |
| CORL23 | disease: carcinoma, large cell |
| COV362 | cell line derived from ovary |
| COV434 | cell line derived from ovary |
| COV504 | cell line derived from ovary |
| COV644 | cell line derived from ovary |
| DBTRG05MG | |
| DKMG | |
| DLD1 | Human colon adenocarcinoma established from a colorectal adenocarcinoma. |
| EFE184 | |
| EFM19 | |
| EFO21 | disease: cystoadenocarcinoma |
| EFO27 | Human ovary adenocarcinoma cell line; established from the solid omental metastasis of a mucinous papillary adenocarcinoma of the ovary of a 36-year-old woman in 1979. |
| EW8 | cell line derived from bone |
| EWS502 | cell line derived from bone |
| F36P | A immortal human bone marrow-derived cell line cell that has the characteristics: GM-CSF- or IL-3-dependent cell line. Differentiate to erythoid cells with erythropoietin. |
| GB1 | cell line derived from central nervous system |
| GP2D | |
| HCC1187 | disease: primary ductal carcinoma |
| HCC1395 | |
| HCC1954 | |
| HCC2218 | disease: primary ductal carcinoma |
| HCC2814 | cell line derived from lung |
| HCC364 | cell line derived from lung |
| HCC44 | |
| HCC70 | disease: primary ductal carcinoma |
| HCC827 | |
| HCC827GR5 | cell line derived from lung |
| HCT116 | Human colon colorectal carcinoma cell line from a male organism. Human colon carcinoma cell line; established from the primary colon carcinoma of an adult man. |
| HEC1A | |
| HEYA8 | cell line derived from ovary |
| HL60 | Human acute myeloid leukemia established from the peripheral blood of a 35-year-old woman with acute myeloid leukemia (AML FAB M2) in 1976. |
| HLF | hepatic leukemia factor|This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| HNT34 | A immortal human blood cell line cell that has the characteristics: AML with Ph' chromosome and t(3;3)(q21;q26). Expressing EVI-1 and BCR/ABL mRNA. |
| HPAC | |
| HPAFII | |
| HS683 | Human brain glioma cell line. Hs 683 was isolated from explant cultures of a glioma taken from the left temporal lobe of a 76 year old male Caucasian. |
| HS766T | Human pancreatic cancer cell line. |
| HS944T | disease: melanoma (skin primary) |
| HT1197 | |
| HT29 | |
| HT55 | |
| HUG1N | A immortal human stomach-derived cell line cell that has the characteristics: Stomach cancer, but producing Nagao-type alkaline phosphatase. See HuG1-PI. |
| HUTU80 | |
| IGR39 | |
| IGROV1 | |
| IOMMLEE | Malignant meningioma cell line. |
| JHESOAD1 | cell line derived from oesophagus |
| JHOC5 | A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Clear cell adenocarcinoma. Said CA125, CA72-4 producing. |
| JHOM1 | A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Human ovary mucinous adenocarcinoma cell line. |
| JJN3 | cell line derived from haematopoietic_and_lymphoid_tissue |
| K562 | Human chronic myeloid leukemia in blast crisis established from the pleural effusion of a 53-year-old woman with chronic myeloid leukemia (CML) in blast crisis in 1970. |
| KALS1 | |
| KASUMI1 | Human acute myelocytic leukemia cell line; derived from the peripheral blood of a 7-year-old japanese boy with acute myelocytic leukemia in relapse after bone marrow transplantation. |
| KM12 | Human colon carcinoma cell line. |
| KMS12BM | cell line derived from haematopoietic_and_lymphoid_tissue |
| KNS60 | cell line derived from central_nervous_system |
| KNS81 | cell line derived from central nervous system |
| KP1NL | cell line derived from pancreas |
| KP2 | Human pancreatic cancer cell line of primary pancreatic origin. |
| KP4 | A immortal human cell line cell that has the characteristics: Pancreatic ductal cell carcinoma. Mother cell line of KP4-1, -2, and -3. |
| KURAMOCHI | |
| KYSE150 | Human esophageal squamous cell carcinoma cell line; established from the poorly differentiated esophageal squamous cell carcinoma resected from upper (cervical) esophagus of a 49-year-old Japanese woman after receiving radiotherapy. |
| KYSE30 | |
| KYSE450 | disease: carcinoma, squamous cell |
| KYSE510 | disease: carcinoma, squamous cell |
| L33 | Human pancreatic cancer cell line. |
| L363 | Multiple myeloma cell line expressing syndecan-1. |
| LAMA84 | Human chronic myeloid leukemia in blast crisis; established from the peripheral blood of a 29-year-old woman with chronic myeloid leukemia. |
| LK2 | A immortal human cell line cell that has the characteristics: Human lung squamous cell carcinoma cell line.TKG0494 (Deposited from Tohoku Univ.). |
| LN215 | Human glioblastoma cell line. |
| LN229 | Human brain, right frontal parieto-occipital cortex, glioblastoma cell line; established from a 60 years old white female. |
| LN235 | Human glioblastoma cell line. |
| LN319 | Anaplastic astrocytoma cell line. |
| LN340 | Human glioblastoma cell line. |
| LN382 | Human glioblastoma cell line. |
| LN428 | Human glioblastoma cell line. |
| LN443 | Human glioblastoma cell line. |
| LN464 | Human glioblastoma cell line. |
| LNZ308 | Human glioblastoma cell line. |
| LOVO | A immortal human colon-derived cell line cell that has the characteristics: CEA-producing colon adenocarcinoma. Back up culture of ECA2739. Cell growth is slow. |
| LS411N | disease: colorectal carcinoma |
| LS513 | disease: colorectal carcinoma |
| MCF7 | A immortal human breast-derived cell line cell that has the characteristics: Human cell line derived from breast adenocarcinoma. TKG0479 (Deposited from Tohoku Univ.). |
| MDAMB453 | |
| MIAPACA2 | A immortal human cell line cell that has the characteristics: Human cell line derived from pancreatic cancer. TKG0227(Deposited from Tohoku Univ.) |
| MKN7 | A immortal human stomach-derived cell line cell that has the characteristics: c-erbB-2 expressing gastric adenocarcinoma. Differentiated type. |
| MM1S | Human B lymphoblast multiple myeloma cell line. |
| MOLM13 | Human acute myeloid leukemia cell line; established from the peripheral blood of a 20-year-old man with acute myeloid leukemia AML FAB M5a at relapse in 1995 after initial myelodysplastic syndromes. |
| MONOMAC1 | Human acute monocytic leukemia cell line; established from the peripheral blood of a 64-year-old man with relapsed acute monocytic leukemia (AML FAB M5) in 1985 following myeloid metaplasia. Simultaneous sister cell line of MONO-MAC-6. |
| MONOMAC6 | Human acute monocytic leukemia cell line; established from the peripheral blood of a 64-year-old man with relapsed acute monocytic leukemia (AML FAB M5) in 1985 following myeloid metaplasia. Sister cell line of MONO-MAC-1. |
| MV411 | Human acute myelocytic leukemia cell line. |
| NALM6 | |
| NB4 | |
| NCIH1299 | |
| NCIH1437 | |
| NCIH1650 | |
| NCIH1792 | disease: adenocarcinoma (lung primary) |
| NCIH196 | Small cell lung cancer cell line. |
| NCIH1975 | |
| NCIH2052 | disease: mesothelioma (pleura primary) |
| NCIH2122 | |
| NCIH2171 | disease: carcinoma; small cell lung cancer (lung primary) |
| NCIH23 | |
| NCIH2452 | disease: mesothelioma |
| NCIH441 | |
| NCIH508 | disease: colorectal adenocarcinoma |
| NCIH660 | Homo sapiens (human) lung; small cell lung cancer cell line, extrapulmonary origin; established from a 63 years adult caucasian male. Morphology: epithelial; cell type: neuroendocrine; Tumor stage E; derived from metastatic site: lymph node. |
| NCIH661 | |
| NCIH716 | |
| NCIH838 | |
| NCIN87 | |
| NIHOVCAR3 | Human caucasian ovary adenocarcinoma cell line; established from a 60 years old caucasian female. |
| NOMO1 | |
| OAW42 | disease: cystoadenocarcinoma |
| OCIAML2 | Human acute myeloid leukemia cell line; established from the peripheral blood of a 65-year-old man with acute myeloid leukemia. |
| OCIAML3 | Human acute myeloid leukemia cell line; established from the peripheral blood of a 57-year-old man with acute myeloid leukemia. |
| OCIAML5 | Human acute myeloid leukemia cell line; established from the peripheral blood of a 77-year-old man with acute myeloid leukemia. |
| OE33 | |
| OELE | cell line derived from ovary |
| OPM2 | |
| OV7 | cell line derived from ovary |
| OV90 | |
| OVCAR4 | |
| OVCAR8 | |
| OVISE | Human ovarian carcinoma cell line from clear cell adenocarcinoma. |
| PANC0327 | |
| PANC0813 | |
| PANC1005 | disease: adenocarcinoma; same patient as PL45 |
| PLB985 | |
| PSN1 | Human pancreatic adenocarcinoma cell line. |
| QGP1 | Human pancreatic neuroendocrine tumor cell line. |
| REH | Human B cell precursor leukemia established from the peripheral blood of a 15-year-old North African girl with acute lymphoblastic leukaemia, ALL at first relapse, in 1973. |
| RKN | cell line derived from soft_tissue |
| RKO | |
| RMGI | Human tumor cell line from ovarian mesonephroid adenocarcinoma. |
| RMUGS | cell line derived from ovary |
| RS411 | Human B cell precursor leukemia cell line; established from the bone marrow of a 32-year-old woman with acute lymphoblastic leukemia (ALL L2) in first relapse. |
| RT112 | Human urinary bladder transitional cell carcinoma established from the transitional cell carcinoma histological grade G2 excised from a female patient with untreated primary urinary bladder carcinoma in 1973. |
| SEM | |
| SF126 | |
| SF172 | cell line derived from central nervous system |
| SF295 | |
| SF767 | Human glioblastoma cell line. |
| SJSA1 | |
| SKCO1 | disease: colorectal adenocarcinoma (colon primary) |
| SKMEL5 | Human caucasian skin melanoma cell line; established from a 24 year old Caucasian female. Derived from: axillary node. |
| SKMM2 | |
| SKNO1 | cell line derived from haematopoietic and lymphoid tissue |
| SKOV3 | |
| SKRC20 | cell line derived from kidney |
| SLR20 | cell line derived from kidney |
| SLR21 | cell line derived from kidney |
| SLR23 | cell line derived from kidney |
| SLR24 | cell line derived from kidney |
| SLR25 | cell line derived from kidney |
| SLR26 | cell line derived from kidney |
| SNU1105 | cell line derived from central_nervous_system |
| SNU840 | cell line derived from ovary |
| SNUC1 | disease: adenocarcinoma colon primary) |
| SNUC2A | disease: colorectal carcinoma |
| SU8686 | Homo sapiens (human) pancreatic adenocarcinoma cell line. The line was developed from a wedge biosy of a liver metastasis of a pancreatic ductal carcinoma. |
| SW1417 | |
| SW1783 | disease: astrocytoma |
| SW48 | |
| SW480 | |
| T98G | A immortal human brain-derived cell line cell that has the characteristics: Human cell line derived from glioblastoma multiforme (Caucasian). Hyperpentaploid chromosome count. TKG0471(Deposited from Tohoku Univ.). |
| TC71 | |
| TCCSUP | disease: transitional cell carcinoma |
| TE10 | A immortal human esophagus-derived cell line cell that has the characteristics: Human cell line derived from esophageal cancer. Highly differentiated squamous cell carcinoma. TKG0261(Deposited from Tohoku Univ.). |
| TE15 | Human esophageal squamous cell carcinoma cell line. |
| TE9 | A immortal human esophagus-derived cell line cell that has the characteristics: Human esophageal squamous cell carcinoma (poorly differentiated) cell line. Not transplantable to nude mouse. TKG0260 (Deposited from Tohoku Univ.). |
| THP1 | |
| TOV112D | TOV-112D is a human epithelial cell line initiated in October of 1992 from a patient with early onset ovarian cancer. The patient was of French-Canadian descent with an unknown family history of ovarian cancer. |
| TOV21G | This cell line was initiated in October of 1991 from a patient of French-Canadian descent with no family history of ovarian cancer. |
| TT | |
| TYKNU | |
| U178 | cell line derived from central nervous system |
| U251MG | Human glioma cell line. Morphology: glial; Species: human; Tumor: glioma. |
| U343 | Human glioma cell line. |
| U87MG | Human, Caucasian, brain, glioblastoma-astrocytoma cell line Morphology: epithelial-like; Species: human, Caucasian female 44 years old; Tissue: brain; Tumor: glioblastoma-astrocytoma. |
| UOK101 | cell line derived from kidney |
| VCAP | Human prostate cancer cell line. |
| YKG1 | A immortal human brain-derived cell line cell that has the characteristics: Human cell line derived from glioblastoma. TKG0453(Deposited from Tohoku Univ.). |
| ZR7530 |
